Blar i forfatter "Anfossi, Simone"

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    • 17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer 

      Drula, Rares; Pardini, Barbara; Fu, Xiao; De Los Santos, Mireia Cruz; Jurj, Ancuta; Pang, Lan; El-Daly, Sherien M.; Fabris, Linda; Knutsen, Erik; Dragomir, Mihnea P.; Bayraktar, Recep; Li, Yongfeng; Chen, Meng; Del Vecchio, Filippo; Berland, Léa; Dae, Jessica; Fan, Daniel; Shimizu, Masayoshi; Tran, Anh M.; Barzi, Mercedes; Pioppini, Carlotta; Gutierrez, Angelica M.; Ivan, Cristina; Meas, Salyna; Hall, Carolyn S.; Alahari, Suresh K.; Berindan-Neagoe, Ioana; Fabbri, Muller; Lucci, Anthony; Arun, Banu; Anfossi, Simone; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-30)
      The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are not yet well understood in malignancies, including in breast cancers (BCs). Given the hormonal signaling dependence of estrogen receptor–positive (ER+) BC, we hypothesized that 17β-estradiol (estrogen) might influence EV production and microRNA (miRNA) loading. We report that physiological doses of 17β-estradiol ...

    • Anti–miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response 

      Dragomir, Mihnea P.; Fuentes-Mattei, Enrique; Winkle, Melanie; Okubo, Keishi; Bayraktar, Recep; Knutsen, Erik; Qdaisat, Aiham; Chen, Meng; Li, Yongfeng; Shimizu, Masayoshi; Pang, Lan; Liu, Kevin; Liu, Xiuping; Anfossi, Simone; Zhang, Huanyu; Koch, Ines; Tran, Anh M.; Mohapatra, Swati; Ton, Anh; Kaplan, Mecit; Anderson, Matthew W.; Rothfuss, Spencer J.; Silasi, Robert; Keshari, Ravi S.; Ferracin, Manuela; Ivan, Cristina; Rodriguez-Aguayo, Cristian; Lopez-Berestein, Gabriel; Georgescu, Constantin; Banerjee, Pinaki P.; Basar, Rafet; Li, Ziyi; Horst, David; Vasilescu, Catalin; Bertilaccio, Maria Teresa S.; Rezvani, Katayoun; Lupu, Florea; Yeung, Sai-Ching; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-01)
      Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncoding miRNAs in sepsis pathogenesis became a dynamic research topic. To screen for new miRNA targets for sepsis therapeutics, we used samples for miRNA ...

    • Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action 

      Untergasser, Andreas; Hellemans, Jan; Pfaffl, Michael W.; Ruijter, Jan M.; van den Hoff, Maurice J. B.; Dragomir, Mihnea P.; Adamoski, Douglas; Dias, Sandra Martha Gomes; Reis, Rui Manuel; Ferracin, Manuela; Dias-Neto, Emmanuel; Marsh, Ian; Kubista, Mikael; Fabbri, Muller; Goel, Ajay; Slabý, Ondřej; Knutsen, Erik; Chen, Baoqing; Negrini, Massimo; Mimori, Koshi; Pichler, Martin; Papatriantafyllou, Maria; Anfossi, Simone; Schmittgen, Thomas D.; Huggett, Jim; Bustin, Stephen; Vandesompele, Jo; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)
      Accuracy and transparency of scientific data are becoming more and more relevant with the increasing concern regarding the evaluation of data reproducibility in many research areas. This concern is also true for quantifying coding and noncoding RNAs, with the remarkable increase in publications reporting RNA profiling and sequencing studies. To address the problem, we propose the following ...

    • A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment 

      Dragomir, Mihnea Paul; Moisoiu, Vlad; Manaila, Roxana; Pardini, Barbara; Knutsen, Erik; Anfossi, Simone; Amit, Moran; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)
      One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ...

    • The long noncoding RNA CCAT2 induces chromosomal instability through BOP1-AURKB signaling 

      Chen, Baoqing; Dragomir, Mihnea Paul; Fabris, Linda; Bayraktar, Recep; Knutsen, Erik; Liu, Xu; Tang, Changyan; Li, Yongfeng; Shimura, Tadanobu; Ivkovic, Tina Catela; Cruz De los Santos, Mireia; Anfossi, Simone; Shimizu, Masayoshi; Shah, Maitri Y.; Ling, Hui; Shen, Peng; Multani, Asha S.; Pardini, Barbara; Burks, Jared K.; Katayama, Hiroyuki; Reineke, Lucas C.; Huo, Longfei; Syed, Muddassir; Song, Shumei; Ferracin, Manuela; Oki, Eiji; Fromm, Bastian; Ivan, Cristina; Bhuvaneshwar, Krithika; Gusev, Yuriy; Mimori, Koshi; Menter, David; Sen, Subrata; Matsuyama, Takatoshi; Uetake, Hiroyuki; Vasilescu, Catalin; Kopetz, Scott; Parker-Thornburg, Jan; Taguchi, Ayumu; Hanash, Samir M.; Girnita, Leonard; Slaby, Ondrej; Goel, Ajay; Varani, Gabriele; Gagea, Mihai; Li, Chunlai; Ajani, Jaffer A.; Calin, George A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-15)
      Background & Aims - Chromosomal instability (CIN) is a carcinogenesis event that promotes metastasis and resistance to therapy by unclear mechanisms. Expression of the colon cancer–associated transcript 2 gene (CCAT2), which encodes a long noncoding RNA (lncRNA), associates with CIN, but little is known about how CCAT2 lncRNA regulates this cancer enabling characteristic.<p> <p>Methods - We ...